On the Hausdorff dimension of CAT(κ\kappa) surfaces

We prove that a closed surface with a CAT($\kappa$) metric has Hausdorff dimension = 2, and that there are uniform upper and lower bounds on the two-dimensional Hausdorff measure of small metric balls. We also discuss a connection between this uniformity condition and some results on the dynamics of the geodesic flow for such surfaces. Finally, we give a short proof of topological entropy rigidity for geodesic flow on certain CAT(-1) manifolds.Comment: 13 pages, 3 figure

Isomorphism versus commensurability for a class of finitely presented groups

We construct a class of finitely presented groups where the isomorphism problem is solvable but the commensurability problem is unsolvable. Conversely, we construct a class of finitely presented groups within which the commensurability problem is solvable but the isomorphism problem is unsolvable. These are first examples of such a contrastive complexity behaviour with respect to the isomorphism problem

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field

Rigidity results for singular spaces.

In this thesis, we discuss various rigidity results for geodesic length spaces that are not Riemannian manifolds. Our results are of two different types. In the first portion of this thesis, we prove a marked length rigidity (MLS) result for metric graphs. We then extend our techniques to prove MLS rigidity for arbitrary length spaces of topological dimension one. Finally, we provide a local MLS rigidity result for P-manifolds in arbitrary dimension. Corollaries of this work include the characterization of harmonic maps between certain metric graphs. We discuss how, for certain spaces, our theorem is equivalent to a weak form of a result of Culler-Morgan on group actions on R -trees. In the second portion of the thesis, we give a proof of Mostow rigidity for certain 3-dimensional hyperbolic P-manifolds that satisfy a large local link condition. As corollaries, we obtain a rigidity result for certain direct limits of diagrams, as well as a quasi-isometry classification for these direct limits.Ph.D.MathematicsPure SciencesUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/132344/2/3057993.pd